effects of solriamfeton on motor function , general activity , และ alertnessใน male sd rats , a single oral administration of 25 or 50 mg / kg solriamfetol slightlyincreased motor activity to saline controls ( study no.95 - 9 , non - glp )in male cd - 1 mice , compared to vehicle controls , a single oral administrationsolriamfetol at 25,50 , or 84 mg / kg slightly increased motor activity ในคอมแพริสันimipramine at 30 mg / kg po reduced motor activity in mice . at higher doses of 672 to1512 mg / kg / kg po , solriamfetol caused a dose - dependent decrease in rotarodperformance in male cd - 1 mice . the median neuro toxic dose for solriamfetol ( td50 )50 % of the mice fails the rotarod test was 1360 mg / kg . imipramine , a tricyclicแอนติ depressant , also dose - dependent ly decreased rotarod performance กับ td50of97 mg / kg , po ( study no . 95 - 16 , non - glp ) . in a spontaneous motor activity testใน male long - evans rats , compared to vehicle controls ( 0 . 5 % w / v methyl cellulose )solriamfetol at 29 mg / kg po induced a moderate increase in horizontal activity but didnot induce anxiogenic effects ( study no . 15756 , non - glp )in male cf - 1 ( car worth farms colony ) mice , compared to vehicle controls ,solriamfetol , at 84 mg / kg po given prior to a non hypnotic dose of ethanol , did notinduce anesthesia ( study no . 1868 ) . in male cd - 1 mice , compared to vehicle controls( saline ) , solriamfetol , at25 และ 84 mg / kg po reduced the mean sleeping time inducedโดย hexobarbital , whereas imipramine at 84 mg / kg po increased the sleeping time
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